Resistance / Risk of triple-negative breast cancer
We developed a multiple-step method to statistically infer the resistance for each individual
by measuring function of a set of pathways disrupted by any rare mutations. Individual can be categorized into five
groups corresponding to the level of TNBC risk/resistance using the germline mutation profiling.
Reference:Germlinegenetics encode the resistance, risk, and lymphatic metastasis of
triple-negative breast cancer in the southern Chinese population. submited
Input VCF file: VCF stands for Variant Call Format. It is a standardized text file format for representing SNP,
indel, and structural variantion calls. The VCF specification can be found on the 1000 Genomes web site(http://www.internationalgenome.org/wiki/Analysis/vcf4.0/).
Users can upload VCF file output by GATK or SAMtools, et al.
Joint reserch project between Phil Rivers Technology and Guangdong General Hospital